REVARESP

Avoidance and resistance to the host’s antimicrobial response in the interaction between oyster and the vibrio splendidus bacteria

Projet en cours

Projet affilié à:
Porteur du projet IFREMER
Partenaires recherche INRA, UM2
Budget 100 K€
Cofinanceur publics ANR
Année de labellisation 2009
Année de cofinancement 2009

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In the context of mass mortalities affecting farmed oysters, Crassostrea gigas, the REVAResp project objective is to understand the molecular mechanisms that allow Vibrio splendidus LGP32, an oyster pathogen associated with summer mortality, to resist and/or avoid the host's antimicrobial defences.

Thus, by the placing the interaction between oyster and Vibrio at the heart of the study, REVAResp will review:

  • the pathogen; in order to identify the Vibrio resistance mechanisms to the immune effector cells which are the oyster’s antimicrobial peptides
  • the host; through the identification of the Vibrio’s moderating effect (stimulating or immuno-suppressive) on the antimicrobial response of the oyster (expression of antimicrobial peptides).

Secondly, REVAResp will evaluate the role of resistance to antimicrobial peptides in Vibrio in adult and juvenile oysters.